beandeau>

Program

 Program July 17th

 

8:30 – Opening - Welcoming remarks 


Anne-Karine Bouzier-Sore, Aude Panatier, Hélène Roumes

 

Neuron / astrocyte metabolic interactions and exchanges          (Chair H. Roumes)

 

9:00 – Luc Pellerin (IRMETIST U1313, Poitiers, France)

Neuronal and Astroglial Lactate Transporters: Regulation and Roles in Hippocampal-Dependent Learning and Memory Performance

9:30 – Rosa Chiara Paolicelli (Department of Biomedical Sciences, Lausanne, Switzerland)

Focus on Lactate in the Control of Microglial Function

10:00 – Vanja Tepavcevic (University of Valencia, Valencia, Spain)

Metabolic Support for Myelin Maintenance and Repair: The Role of Monocarboxylates and Their Transporters

 

10:30 – 11:00  Coffee break

 

11:00 – Aude Panatier (Unité Physiopathologie de la Plasticité Neuronale Inserm 1215, Bordeaux, France)

Glucose and Lactate: From Basal Synaptic Transmission to Neuron Excitability

11:30 – Felipe Barros (Centro de Estudios Científicos - CECs, Valdivia, Chile)

Mitochondrial Lactate: a New Player in Energy Metabolism

12:00 – Anne-Karine Bouzier-Sore (CRMSB UMR5536, Bordeaux, France)

Metabolic Interactions Between Neurons and Astrocytes: From Brain Activation to Neuroprotection

 

12:30 – 14:00  Lunch (Hall, Haut-Carré, Bordeaux)

 

Students and young researchers’ communications                                    (Chair A. Panatier)

 

14:00 – 15:30 Students and young researchers' presentations & flash posters (part 1)

 

Probing transient changes in intracellular-extracellular lactate distribution in the mouse brain during intravenous lactate infusion using diffusion-weighted MR spectroscopy. S. Malaquin et al.

The monocarboxylate transporter MCT1 is on-board of axonal vesicles and uploads lactate produced by vesicular glycolysis: consequences for axonal transport and neuronal signalling. A. Procès et al.

Chemogenetic stimulation of mature oligodendrocytes drives myelin-axon metabolic coupling and prevents axonal damage. A. Palma et al.

Exploring brain glucose metabolism in multiple sclerosis: A deuterium metabolic imaging study. A.S. Khan et al.

GLUT1 Deficiency Syndrome: New Horizon. L. Dayraut et al.

Glycogen-derived lactate accelerates tissue repolarization during spreading depolarization. S. Chen et al.

 

15:30 – 16:00 Coffee break & poster session

 

ALS may be a disease arising from human evolution to run, via gangliosides and lactate: therapeutic opportunities. M. Spedding

Lactate fuels TCA cycle flux and modulates mitochondrial function in microglia. K. Monsorno et al.

Effects of a ketogenic diet on neuronal and astrocytic metabolism in the mouse brain: A two-photon FLIM study. R. Meister et al.

Altered neuronal lactate dehydrogenase a expression in mice results in changes to spatial memory and lipid droplet formation depending on sex and age. M. Courchesne et al.

Phenotypical alterations in mice deficient in astrocytic mitochondrial complex I. M.L. Hidalgo López et al.

Deletion of MonoCarboxylate Transporter 1 in myeloid cells favours glioblastoma development. S. Lillo et al.

Probing metabolic tuning of neurovascular coupling by multimodal imaging and optogenetics. C. Lupiet et al.

 The role of glucose and lactate to sustain basal synaptic transmission and excitability. J. Garcia-Ruiz et al.

The synthetic cannabinoid URB447 promotes neuroprotection in a neonatal rat model of hypoxic-ischemic brain injury. M. Chillida et al.

Astrocyte metabolism as an epigenetic regulator of neural functions during cognitive decline. M. Antequera et al.

Modeling neurovascular coupling. L. Benyakar et al.

Eco-friendly grape polyphenols offer neuroprotection in neonatal hypoxia-ischemia. P. Goudeneche et al.

Unravelling the role of lactate produced by axonal vesicles on axonal transport and neurotransmission. B. Nicolas et al.

GluCEST as a translational biomarker of synaptic dysfunction in Alzheimer's disease. E.G. Senneset et al.

 

16:00 – 17:30 Students and young researchers' presentations & flash posters (part 2)

Investigating hub homeostasis alterations in focal epilepsy using 7T sodium and diffusion MRI. L. Gauer et al.

Associations between cognitive performance and brain metabolism in individuals with Long-COVID. A.P. Bornes da Silva et al.

Lactate: a promising therapeutic approach in the context of neonatal hypoxia-ischemia. I. Omar et al.

Isocaloric time-restricted feeding to fight aged-associated behavioral anomalies by western diet. D. Passaro et al.

Characterization of a new mitochondrial disease associated with SLC25A2/ANT2 loss of function. C. Berges et al.

The role of GLUT3 in neuronal energy metabolism and cognitivefunctions involving the rat somatosensory cortex. M.A. Zkim et al.

 

17:00  Wine and cheese and poster session

 

 

 

Program July 18th

 

Metabolic Interplay Between Neurons and Astrocytes: Implications for Neuroprotection  

(part 1)          (Chair A-K. Bouzier-Sore)

  

9:00 – Pierre Magistretti (GliaPharm SA, Geneva, Switzerland)

Neuron-Glia Metabolic Coupling Mediated by Lactate: Relevance for Neuroenergetics, Plasticity and Pathology

9:30 – Michèl Willemsen (Department of Pediatric Neurology, Amalia Children's Hospital, Nijmegen, The Netherlands)

Glucose Transporter 1 Deficiency Syndrome: Disease Mechanisms and Therapeutic Perspectives

10:00 – Nikki Robertson (University of Edinburgh, Edinburgh, United Kingdom)

Neonatal Brain Protection and the Use of Brain Lac/NAA in MRS as a Surrogate Outcome Marker

 

10:30 – 11:00  Coffee break

 

Round table: meeting between scientists and physicians               (Chair F. Villéga)

11:00 – 12:30 Round table (part 1)

 

12:30 – 14:00  Lunch (Hall, Haut-Carré, Bordeaux)

 

Metabolic Interplay Between Neurons and Astrocytes: Implications for Neuroprotection 

(part 2)  (Chair A-K. Bouzier-Sore)

 

14:00 –   Johanne Egge Rinholm (Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway)

Cell-Type Specific Responses to Ischemic Brain Injury: From Mouse Models to Human Organoids

14:30 – Eduardo Zimmer (UFRGS, Porto Alegre, Brazil)

 About Astrocytes in Alzheimer’s Disease.

15:00 – Thomas Daubon (IBGC, UMR 5095, Bordeaux, France)

Lactate Shuttle Between Glioblastoma Cells and Neurons : A Cancer Neuroscience Case 

 

15:30 – 16:00  Coffee break

 

Round table: meeting between scientists and physicians               (Chair F. Villéga)

16:00 – 17:00 Round table (part 2)

 

17:00 – 17:15 Deliberation to award the poster, flash poster and communication prizes

 

17:15 – 17:30 Award ceremony 

 

17:30 – 18:00 Conclusions and closing of the scientific symposium

 

 

 

 

 
Loading... Loading...